Science and Nature

A chain alternate in a single protein allowed a tomato virus to turn actual into a worldwide gash pandemic

A sequence change in a single protein allowed a tomato virus to become a global crop pandemic
Tomato flora (cv. Moneymaker) (upper panel) and leaves (lower panel) homozygous to the tm-2 or Tm-22 allele infected with ToMV and ToMVMP-ToBRFV. Credit: Hagit Hak and Ziv Spiegelman

Within the closing years, a brand novel viral tomato illness has emerged, threatening tomato production worldwide. Here is precipitated by the Tomato brown rugose fruit virus (ToBRFV), a member of a devastating crew of plant viruses called tobamoviruses. ToBRFV overcomes all known tobamovirus resistance in tomato, in conjunction with the one conferred by Tm-22, a resistance gene to blame for the true resistance to those viruses for added than 60 years. In a look as of late published in the Molecular Plant-Microbe Interactions (MPMI), journal, Dr. Ziv Spiegelman and Dr. Hagit Hak explored the molecular mechanism by which this emerging virus change into as soon as ready to successfully ruin this resistance and turn actual into a devastating global gash pandemic.

“Tm-22 encodes a plant immune receptor protein, which acknowledges a viral-encoded protein named motion protein, triggering an immune response in opposition to a large series of tobamoviruses. ToBRFV is the first virus that change into as soon as ready to beat the durable Tm-22 resistance gene,” stated Spiegelman. “We found that the ToBRFV motion protein harbored sequence adjustments that enable it to evade Tm-22. We confirmed this by introducing this novel sequence to yet every other virus (the tomato mosaic virus) that customarily can no longer infect flora harboring Tm-22, which resulted in a virulent virus.”

Furthermore, they came up with an enticing observation from an evolutionary level of look. “Viral motion proteins enable the virus to unfold from cell to cell and infect the full plant. We found that the capabilities that enabled the motion protein to lead sure of Tm-22 recognition seemingly resulted in diminished viral motion. This implies that the virus pays a penalty for evading host resistance, which is a diminished cell-to-cell transport. This discovering might moreover honest sing the high sturdiness of Tm-22 resistance, which had remained unbroken for over half a century,” stated Spiegelman.

More recordsdata:
Hagit Hak et al, The Tomato Brown Rugose Fruit Virus Circulate Protein Overcomes Tm-22 Resistance in Tomato While Attenuating Viral Transport, Molecular Plant-Microbe Interactions (2021). DOI: 10.1094/MPMI-01-21-0023-R

Offered by
American Phytopathological Society

A chain alternate in a single protein allowed a tomato virus to turn actual into a worldwide gash pandemic (2021, November 2)
retrieved 2 November 2021

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