Science and Nature

Cavernous lesions

Blood vessels within the mind supply oxygen but furthermore enable circulation of assorted molecules, ions, and cells between the blood and the mind. About one in 200 folks have faith cerebral cavernous malformations (CCMs), that are irregular collections of itsy-bitsy cerebral vessels that alter the circulation of blood and can result in complications, seizure, hemorrhage, paralysis, or stroke. Li et al. dilapidated the zebrafish model machine and CRISPR-Cas9 mutagenesis to inactivate the CCM gene. Consequently, the caudal venous plexus became dilated, “honeycombing” of the vein lumen disrupted blood circulation, and loads of blood-stuffed chambers with a possibility of hemorrhaging formed.

eLife 10.7554/eLife.62155 (2021).

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