Metastasis is when cancer becomes deadly. Unsuccessful searches for driver mutations of metastasis maintain led some to uncover more than just a few epigenetic causes. Pierce et al. found that the protein kinase LKB1, greater identified for influencing cancer by legislation of metabolism, had a tumor-suppressive characteristic in a single mouse lung cancer model. This tumor develops largely due to epigenomic results on chromatin accessibility. Loss of LKB1 prompts sure waves of epigenetic remodeling in main and metastatic tumor cells. Metastasis was mediated by activation of the transcription ingredient SOX17. The authors had been then in a region to detect a shrimp population of cells in main tumors with the epigenetic traits of later metastatic cells, revealing a promising therapeutic goal.
Nat. Cell Biol. 23, 915 (2021).