Elevated serum magnesium levels appear to lower the threat for intracranial aneurysm and aneurysmal subarachnoid hemorrhage. The outcomes will likely be partially mediated by magnesium’s impact on systolic blood stress, recent learn suggests.
“The modifiable threat components for intracranial aneurysm are largely unknown. Our findings equipped proof of a causal affiliation between increased serum magnesium levels and reduced threat of intracranial aneurysm,” Susanna Larsson, PhD, Karolinska Institutet, Stockholm, Sweden, told Medscape Scientific Files.
These outcomes counsel that raising serum magnesium levels ― thru a magnesium-rich weight reduction program or magnesium supplementation ― “could well play a job within the principle prevention of intracranial aneurysm and connected hemorrhage,” Larsson added.
The gaze used to be printed online June 22 in Neurology.
Decrease Likelihood for Atomize
The researchers leveraged randomly disbursed genetic variants connected to serum magnesium concentrations in a two-sample Mendelian randomization (MR) gaze to evaluate whether or no longer higher genetically predicted serum magnesium correlates with reduced threat for intracranial aneurysm. They also conducted a multivariable MR diagnosis to evaluate the role blood stress could well play in this affiliation.
Source info came from a genome-wide affiliation gaze (GWAS) entertaining 23,829 participants that previously known 5 single-nucleotide polymorphisms connected to serum magnesium. Genetic affiliation estimates for intracranial aneurysm had been derived from a GWAS in 79,429 other folks (7495 case patients and 71,934 control patients), and genetic affiliation estimates for systolic blood stress had been derived from a GWAS of 757,601 participants.
The researchers found out that higher genetically predicted serum magnesium concentrations had been connected to lower threat for intracranial aneurysm.
The chances ratios per 0.1 mmol/L increment in genetically predicted serum magnesium concentrations had been 0.66 (95% CI: 0.49 – 0.91) for intracranial aneurysm (unruptured and ruptured blended), 0.57 (95% CI: 0.30 – 1.06) for unruptured intracranial aneurysm, and zero.67 (95% CI: 0.48 – 0.92) for aneurysmal subarachnoid hemorrhage.
Adjustment for genetically predicted systolic blood stress partially attenuated the associations of genetically predicted serum magnesium with all three outcomes, suggesting that magnesium’s impact used to be no longer lower than partially mediated by systolic blood stress.
“As neatly as to a blood stress lowering attain, increased magnesium concentrations could well lower the threat of intracranial aneurysm shatter by bettering endothelial characteristic and reducing oxidative stress,” the investigators expose.
They warning that the data had been derived from other folks of European ancestry, which limits the generalizability to other populations.
“Caution must be taken when extrapolating findings from MR to infer the attain of a scientific intervention, and scientific trials are warranted to handbook optimal apply,” they add.
Essential Role in Vascular Health
In an accompanying editorial, Joanna Pera, MD, PhD, of Jagiellonian University Scientific School, in Krakow, Poland, and Christopher Anderson, MD, of Brigham and Girls folks’s Scientific institution, in Boston, Massachusetts, expose that the gaze “provides to our determining of the importance of magnesium in vascular health significantly connected to cerebral aneurysms.”
There could be a necessity for “both mechanistic and most certainly therapeutic investigation into the role that magnesium performs in subarachnoid hemorrhage,” they add.
Additional, they write, the outcomes “elevate entertaining recent questions in regards to the hyperlinks between circulating magnesium, intracranial aneurysms, and blood stress. Arterial hypertension is a notorious threat sigh for intracranial aneurysm trend and shatter. Magnesium supplementation could well lower blood stress values.
“Would possibly possibly possibly also this mineral expose worthwhile in organising interventions that could stop intracranial aneurysm trend and/or shatter over and above a straightforward lowering of blood stress, perchance thru pleiotropic effects on endothelial characteristic or other mechanisms? With these outcomes in hand, work is clearly wished to learn more in regards to the biology of magnesium within the vascular draw and in intracranial aneurysm biology significantly,” Pera and Anderson halt.
This gaze used to be supported by the Swedish Analysis Council for Health, Working Lifestyles and Welfare, the British Heart Foundation Analysis Heart of Excellence at Imperial School London, and a Nationwide Institute for Health Analysis Clinical Lectureship at St. George’s, University of London. Larsson has disclosed no connected monetary relationships. Gill is employed portion time by Novo Nordisk. Pera has disclosed no connected monetary relationships. Anderson has obtained learn toughen from the Bayer AG and has consulted for ApoPharma and Invitae.