Beyond down-regulating cortical task, sleep furthermore promotes prolonged-timeframe memory formation and the strengthening of synaptic connections. It’s imaginable that every core sleep stages, leisurely-wave sleep (SWS) and snappy ponder movement (REM) sleep, contribute to those processes. Niethard et al. frail in vivo two-photon calcium imaging in mice to assess the task of massive populations of cortical layer 2/3 cells all over SWS and REM sleep. Most pyramidal neurons substantially reduced their task all over SWS and REM sleep episodes. The decrease all over SWS sleep, but no longer all over REM sleep, used to be accompanied by elevated inhibitory interneuron task. Alternatively, a subpopulation of pyramidal cells exhibited upregulated task all over SWS. These neurons are maybe inflamed about memory formation, and furthermore underwent profound down-regulations all over subsequent REM sleep.
J. Neurosci., 41, 4212 (2021).