Researchers from Karolinska Institutet contain stumbled on how platinum chemotherapy can make stronger the remedy resistance of ovarian cancer cells, by step by step changing the cancer cell-intrinsic adhesion signaling and cell-surrounding microenvironment.
Platinum chemotherapy is normal remedy in ovarian cancers, but remedy resistance assuredly develops. The extracellular matrix (ECM)-derived biochemical and mechanical cues in the tumor microenvironment are identified to contribute to the flexibility of cancer cells to metastasize and resist remedy. Alternatively, how the dynamic communication between the cancer cells and the ECM is laid low with, or influences the illness progression and chemotherapy, contain remained elusive.
A brand new be taught about led by Kaisa Lehti, researcher on the Department of Microbiology, Tumor and Cell Biology at KI, and published in Nature Communications, reveals that the ECM microenvironment is modulated in metastasis and following chemotherapy. Adjustments in the ECM proteins variably altered the cell loss of life response of the tumor cells.
“Particularly in essentially the most aggressive precise tumor tissues, cancer cells are surrounded by a prominent fibrotic community of proteins like collagens, identified as the extracellular matrix (ECM) and also outlined as the matrisome when notion to be with various related factors together with cytokines and chemokines. The ECM/matrisome is produced largely by stromal cells, but sensed and made over collectively by the cancer cells and the cells of the fibrotic tumor stroma. In tumor cells, explicit ECM signaling in stiff microenvironment critically increased their resistance towards platinum-mediated, apoptosis-inducing DNA hurt,” Kaisa Lehti explains.
Elina A. Pietilä et al, Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance, Nature Communications (2021). DOI: 10.1038/s41467-021-24009-8
Platinum-chemotherapy can make stronger the remedy resistance of ovarian cancer cells (2021, June 24)
retrieved 24 June 2021
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