Science and Nature

Repeat after Me(CP2)!


Rett syndrome (RTT) is a devastating neurodevelopmental disease resulted in basically by loss-of-characteristic mutations in methyl-CpG-binding protein 2 (MECP2) (1). MeCP2 is a DNA binding protein (2) that controls gene expression, nonetheless the explicit molecular mechanism one day of which MeCP2 loss drives RTT pathology stays unclear, partly due to the a decided DNA motif that specifies MeCP2-DNA interactions is lacking. On net page 1411 of this topic, Ibrahim et al. (3) cloak that MeCP2 binds modified cytosine in cytosine-adenine (CA) dinucleotide repeats, offering a modern signature DNA motif for MeCP2 binding. MeCP2 protects CA repeats from high nucleosome occupancy, raising questions about the outcome of this binding on affirming chromatin structure in neurons.

Related Articles

Back to top button
%d bloggers like this: